Randomized trial of electrodynamic microneedle combined with 5% minoxidil topical solution for the treatment of Chinese male Androgenetic alopecia

J Cosmet Laser Ther. 2020;22(1):1-7. doi: 10.1080/14764172.2017.1376094. Epub 2020 Jan 7.


Background: In treating androgenetic alopecia, 5% minoxidil is a commonly used topical drug. By using electrodynamic microneedle at the same time may increase absorption of minoxidil and further stimulate hair growth.Objective: A 24-week, randomized, evaluator blinded, comparative study was performed to evaluate the efficacy of treating Chinese male androgenetic alopecia using microneedle combined with 5% minoxidil topical solution. Methods: Randomized subjects received topical 5% minoxidil (group 1, n = 20), local electrodynamic microneedle treatments (group 2, n = 20), or local electrodynamic microneedle treatments plus topical 5% minoxidil (group 3, n = 20). A total of 12 microneedle treatments were performed every 2 weeks with 2ml 5% minoxidil delivery in group three during each microneedle treatment. Patient receiving topical 5% minoxidil applied 1 ml of the solution twice daily over the course of the study. A total of 60 Chinese male subjects with Norwood-Hamilton type III-VI androgenetic alopecia were treated.Results: The mean improvement in total hair density from baseline to 24 weeks was 18.8/cm2 in group 1, 23.4/cm2 in group 2, and 38.3/cm2 in group 3. The hair growth in the three groups was significantly different (P = 0.002), but there were no significant differences in toxicity found between the three groups.Conclusions: Treatment with microneedle plus topical 5% minoxidil was associated with the best hair growth.

Keywords: Androgenetic alopecia; Chinese; microneedle; minoxidil.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Alopecia / drug therapy*
  • Double-Blind Method
  • Electric Stimulation Therapy / methods*
  • Hair / drug effects
  • Hair / growth & development*
  • Humans
  • Injections, Intradermal / methods
  • Male
  • Middle Aged
  • Minoxidil / administration & dosage*
  • Needles*
  • Treatment Outcome


  • Minoxidil