Human red cell volume regulation in hypotonic media

Comp Biochem Physiol A Comp Physiol. 1988;90(4):533-7. doi: 10.1016/0300-9629(88)90663-9.


1. There is substantial evidence for a volume-sensitive KCl cotransport system in young human RBC. 2. The KCl cotransport system becomes latent on cell maturation. 3. There is a correlation between the activation of the KCl cotransporter by either pressure, NEM, ghosting or in certain anemias with disc/cup cell shape change. 4. The stretch-activated KCl transporter may be coupled to some component of the cell cytoskeleton.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Erythrocyte Volume*
  • Humans
  • Hypotonic Solutions
  • Sheep


  • Hypotonic Solutions