Protracted tinnitus after discontinuation of long-term therapeutic use of benzodiazepines

J Clin Psychopharmacol. 1988 Oct;8(5):359-62.


The presence of protracted tinnitus after discontinuation of long-term therapeutic doses of diazepam (less than or equal to 30 mg/day) is described in three patients. In one of these patients, the association of the tinnitus appearance with the drug discontinuation was documented in a double-blind, randomized, crossover single case study. Objective confirmation of drug use or of abstinence was performed by obtaining plasma benzodiazepine concentrations. The findings provide further documentation that sensory disturbances of short- and long-term duration are among the most distinctive clinical features of the benzodiazepine withdrawal syndrome.

Publication types

  • Case Reports
  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anti-Anxiety Agents / adverse effects*
  • Benzodiazepines
  • Humans
  • Male
  • Middle Aged
  • Substance Withdrawal Syndrome*
  • Tinnitus / etiology*


  • Anti-Anxiety Agents
  • Benzodiazepines