UK Consensus on Normal Tissue Dose Constraints for Stereotactic Radiotherapy

Clin Oncol (R Coll Radiol). 2018 Jan;30(1):5-14. doi: 10.1016/j.clon.2017.09.007. Epub 2017 Oct 13.


Six UK studies investigating stereotactic ablative radiotherapy (SABR) are currently open. Many of these involve the treatment of oligometastatic disease at different locations in the body. Members of all the trial management groups collaborated to generate a consensus document on appropriate organ at risk dose constraints. Values from existing but older reviews were updated using data from current studies. It is hoped that this unified approach will facilitate standardised implementation of SABR across the UK and will allow meaningful toxicity comparisons between SABR studies and internationally.

Keywords: Constraints; OAR; SABR; SBRT; normal tissue; stereotactic radiotherapy.

MeSH terms

  • Consensus
  • Guidelines as Topic
  • Humans
  • Radiosurgery / methods*
  • United Kingdom