The evaluation and management of respiratory disease in children with Down syndrome (DS)

Haya S Alsubie; Dennis Rosen

doi:10.1016/j.prrv.2017.07.003

The evaluation and management of respiratory disease in children with Down syndrome (DS)

Paediatr Respir Rev. 2018 Mar:26:49-54. doi: 10.1016/j.prrv.2017.07.003. Epub 2017 Aug 23.

Authors

Haya S Alsubie¹, Dennis Rosen²

Affiliations

¹ Specialized Medical Center, Department of Pediatric Respiratory Medicine, Sleep Disorders Center, Box 84350, Riyadh 11671, Saudi Arabia. Electronic address: haya392@hotmail.com.
² Harvard Medical School, Boston, MA, USA; Division of Respiratory Diseases, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.

PMID: 29033214
DOI: 10.1016/j.prrv.2017.07.003

Abstract

Children with Down syndrome (DS) have wide range of respiratory problems. Although underlying abnormalities in the respiratory system are important causes of morbidity and mortality in children with DS, particularly in the young, abnormalities in other organ systems may also impact respiratory function. A comprehensive evaluation of the child with DS and respiratory disease may prevent short-term morbidity and mortality, and reduce the incidence of complications in the long term. This review provides an overview of the various causes of respiratory disease, and insight into some of the newer therapies available to treat obstructive sleep apnea, in this population.

Keywords: Adenotonsillectomy; Congenital Heart Disease; Gastroesophageal reflux; Polysomnography; Recurrent wheeze; Upper airway obstruction.

Publication types

Review

MeSH terms

Child
Down Syndrome / complications*
Humans
Patient Care Management / methods*
Respiratory Function Tests
Respiratory Tract Diseases* / complications
Respiratory Tract Diseases* / diagnosis
Respiratory Tract Diseases* / therapy