Endothelin: an important factor in acute renal failure?

Lancet. 1988 Nov 19;2(8621):1179-82. doi: 10.1016/s0140-6736(88)90243-7.


Very low concentrations of the vasoconstrictor peptide endothelin cause intense long-lasting renal vasoconstriction. In the isolated perfused rat kidney, the concentration of endothelin required to reduce blood-flow by 50% is 200 pmol/l, compared with 1000 pmol/l angiotensin II (previously the most potent known vasoconstrictor). Whereas angiotensin II has little effect on the glomerular filtration rate (GFR), a rise in endothelin from 100 to 800 pmol/l reduces GFR by 90%. Endothelin is probably present in the circulation at low concentrations in vivo; events associated clinically with acute renal failure would tend to increase this concentration. Endothelin may be a mediator in the pathogenesis of acute renal failure.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acute Kidney Injury / physiopathology*
  • Adenosine / metabolism
  • Animals
  • Dose-Response Relationship, Drug
  • Endothelins
  • Glomerular Filtration Rate / drug effects
  • Kidney / blood supply
  • Peptides / administration & dosage
  • Peptides / pharmacology*
  • Rats
  • Renal Circulation / drug effects


  • Endothelins
  • Peptides
  • Adenosine