Ketamine blocks an NMDA receptor-mediated component of synaptic transmission in rat hippocampus in a voltage-dependent manner

Neurosci Lett. 1988 Oct 5;92(2):213-7. doi: 10.1016/0304-3940(88)90063-8.

Abstract

We have examined the voltage dependence of the effects of ketamine on synaptic currents in hippocampal CA1 neurons in vitro under conditions where there is a large N-methyl-D-aspartate (NMDA) receptor mediated component of the response. Ketamine reduced inward currents to a greater extent than outward currents of a corresponding size. D-2-Amino-5-phosphonovalerate (APV) substantially reduced the residual outward currents recorded in ketamine, but had only a small effect on the residual inward ones. It is concluded that in this system the action of ketamine in blocking synaptically evoked NMDA receptor-mediated currents shows some voltage dependence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2-Amino-5-phosphonovalerate
  • Animals
  • Hippocampus / drug effects
  • Hippocampus / physiology*
  • In Vitro Techniques
  • Ketamine / pharmacology*
  • Rats
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter / drug effects
  • Receptors, Neurotransmitter / physiology*
  • Synaptic Transmission / drug effects*
  • Valine / analogs & derivatives
  • Valine / pharmacology

Substances

  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter
  • Ketamine
  • 2-Amino-5-phosphonovalerate
  • Valine