An Embedded Real-Time Processing Platform for Optogenetic Neuroprosthetic Applications

IEEE Trans Neural Syst Rehabil Eng. 2018 Jan;26(1):233-243. doi: 10.1109/TNSRE.2017.2763130. Epub 2017 Oct 16.


Optogenetics offers a powerful new approach for controlling neural circuits. It has numerous applications in both basic and clinical science. These applications require stimulating devices with small processors that can perform real-time neural signal processing, deliver high-intensity light with high spatial and temporal resolution, and do not consume a lot of power. In this paper, we demonstrate the implementation of neuronal models in a platform consisting of an embedded system module and a portable digital light processing projector. As a replacement for damaged neural circuitry, the embedded module processes neural signals and then directs the projector to optogenetically activate a downstream neural pathway. We present a design in the context of stimulating circuits in the visual system, but the approach is feasible for a broad range of biomedical applications.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Algorithms
  • Computer Systems
  • Humans
  • Models, Neurological
  • Neural Pathways
  • Neural Prostheses*
  • Optogenetics / methods*
  • Prosthesis Design*
  • Signal Processing, Computer-Assisted
  • Software