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Randomized Controlled Trial
. 2017 Oct 16;7(10):e289.
doi: 10.1038/nutd.2017.37.

Effect of Anthelmintic Treatment on Leptin, Adiponectin and Leptin to Adiponectin Ratio: A Randomized-Controlled Trial

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Free PMC article
Randomized Controlled Trial

Effect of Anthelmintic Treatment on Leptin, Adiponectin and Leptin to Adiponectin Ratio: A Randomized-Controlled Trial

D L Tahapary et al. Nutr Diabetes. .
Free PMC article

Abstract

Emerging evidence suggests that helminths might confer protection against the development of type 2 diabetes. We aimed to assess the role of adipokines in mediating the effect of helminths on insulin resistance. Serum samples were obtained from a randomized-controlled trial of anthelmintic treatment in an area endemic for soil-transmitted helminths (STH), Flores Island, Indonesia. In STH-infected subjects, anthelmintic treatment significantly increased the ratio of leptin to adiponectin (treatment effect factor (95% confidence interval (CI)), P-value for interaction: 1.20 (1.06-1.35), P=0.010), which largely stemmed from a significant reduction in adiponectin (0.91 (0.85-0.98), P=0.020) and a trend for an increase in leptin level (1.10 (1.00-1.21), P=0.119). No significant effect on resistin level was observed. This increase in leptin to adiponectin ratio seemed to contribute to the observed effect of deworming on increased insulin resistance (IR) as adjustment for leptin to adiponectin ratio attenuated the effect on IR from 1.07 (1.01-1.14, P=0.023) to 1.05 (0.99-1.11, P=0.075). Anthelmintic treatment in STH-infected subjects increases leptin to adiponectin ratio which may in small part contribute to the modest increase in IR. Further studies will be needed to assess the effect of the changes in adipokine levels on the host immune response and metabolism.

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Effect of anthelmintic treatment on adiponectin, leptin, resistin, and leptin to adiponectin ratio in soil-transmitted helminth (STH)-infected and uninfected subjects. The effect of anthelmintic treatment on adiponectin (ADI), leptin (LEP), resistin (RES) and leptin to adiponectin ratio (L/A) in (a) STH-uninfected and (b) STH-infected subjects, as assessed by microscopy, are presented as proportion of changes (95% CI) between pre and post treatment in the albendazole group compared with the placebo group which is set to zero. Adiponectin, leptin, resistin and L/A ratio were log-transformed for analysis. Analysis was performed on 1183 subjects, after excluding 12 subjects with diabetes. Treatment effect estimates were the regression coefficient (β) obtained from mixed models indicating changes in log (ADI or LEP or RES or L/A); the treatment effect factors (10β) are proportional instead of additive. Thus, treatment effect factors indicate the proportional change in each variable in comparison to the placebo group. *P<0.05.

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