Abstract
The molecular and cellular actions of three classes of abused drugs--opiates, psychostimulants, and ethanol--are reviewed in the context of behavioral studies of drug dependence. The immediate effects of drugs are compared to those observed after long-term exposure. A neurobiological basis for drug dependence is proposed from the linkage between the cellular and behavioral effects of these drugs.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Behavior, Animal / drug effects
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Brain / physiopathology*
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Cocaine / pharmacology*
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Drug Tolerance
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Ethanol / pharmacology*
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Humans
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Neurotransmitter Agents / physiology
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Opium / pharmacology*
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Reinforcement, Psychology
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Substance-Related Disorders / physiopathology*
Substances
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Neurotransmitter Agents
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Ethanol
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Opium
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Cocaine