[Initial results of genetic carrier diagnosis in risk pedigrees with hemophilia A and B in East Germany]

Z Gesamte Inn Med. 1988 Aug 15;43(16):441-4.
[Article in German]


In 7 families at risk for hemophilia A 42 individuals were evaluated by the Taq I polymorphism of the extragenic probe St 14.1 and the Bcl I as well the Hind III polymorphism of the intragenic probe F8e16-19. 15 out of 20 females of the core families were identified as carriers, under them all of the obligate heterozygotes. 5 individuals were excluded as carriers. The heterozygosity for each of the RFLPs was found to be between 30% and 79%. Combining the single data in 96% heterozygosity was found under the individuals tested. A linkage disequilibrium was found between the Bcl I and Hind III polymorphismus of the probe F8e16-19. A family at risk for hemophilia B including 5 individuals was studied using the Taq I and Xmn I polymorphisms of the probe P1. In one of two females the carrier state could be excluded in the other one confirmed.

MeSH terms

  • Genetic Carrier Screening*
  • Genetic Counseling
  • Hemophilia A / genetics*
  • Hemophilia A / prevention & control
  • Hemophilia B / genetics*
  • Hemophilia B / prevention & control
  • Humans
  • Pedigree
  • Polymorphism, Restriction Fragment Length
  • Prenatal Diagnosis
  • Risk Factors