Prostate-Specific Membrane Antigen in Low-Grade Fibromatosis

Clin Nucl Med. 2017 Dec;42(12):945-946. doi: 10.1097/RLU.0000000000001854.

Abstract

We report a case of fibromatosis demonstrating prostate-specific membrane antigen (PSMA)-positive scan. A 76-year-old man was under assessment because of rising prostate-specific antigen level. Bone scan showed abnormal soft tissue uptake of Tc-MDP adjacent to the right scapula, compatible with a mass in MRI, thereafter. Because of the unavailability of Ga-PSMA scan in our department and also high cost in other centers, the patient underwent Lu-PSMA for more assessment, which revealed PSMA-avid mass. Pathologic examination confirmed the diagnosis of low-grade fibromatosis. This report demonstrates another false-positive result of PSMA scan and highlights the importance of pathologic examination.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antigens, Surface / metabolism*
  • False Positive Reactions
  • Fibroma / diagnostic imaging
  • Fibroma / metabolism*
  • Fibroma / pathology*
  • Glutamate Carboxypeptidase II / metabolism*
  • Humans
  • Male
  • Neoplasm Grading

Substances

  • Antigens, Surface
  • FOLH1 protein, human
  • Glutamate Carboxypeptidase II