Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 12 (11), 1783-1792

Divergent Effects of Oxytocin on (Para-)Limbic Reactivity to Emotional and Neutral Scenes in Females With and Without Borderline Personality Disorder

Affiliations

Divergent Effects of Oxytocin on (Para-)Limbic Reactivity to Emotional and Neutral Scenes in Females With and Without Borderline Personality Disorder

Alexander Lischke et al. Soc Cogn Affect Neurosci.

Abstract

Borderline personality disorder (BPD) patients' hypersensitivity for emotionally relevant stimuli has been suggested be due to abnormal activity and connectivity in (para-)limbic and prefrontal brain regions during stimulus processing. The neuropeptide oxytocin has been shown to modulate activity and functional connectivity in these brain regions, thereby optimizing the processing of emotional and neutral stimuli. To investigate whether oxytocin would be capable of attenuating BPD patients' hypersensitivity for such stimuli, we recorded brain activity and gaze behavior during the processing of complex scenes in 51 females with and 48 without BPD after intranasal application of either oxytocin or placebo. We found divergent effects of oxytocin on BPD and healthy control (HC) participants' (para-)limbic reactivity to emotional and neutral scenes: Oxytocin decreased amygdala and insula reactivity in BPD participants but increased it in HC participants, indicating an oxytocin-induced normalization of amygdala and insula activity during scene processing. In addition, oxytocin normalized the abnormal coupling between amygdala activity and gaze behavior across all scenes in BPD participants. Overall, these findings suggest that oxytocin may be capable of attenuating BPD patients' hypersensitivity for complex scenes, irrespective of their valence.

Keywords: amygdala; borderline personality disorder; eye tracking; functional magnetic resonance imaging; insula; oxytocin.

Figures

Fig. 1.
Fig. 1.
Brain regions showing activity changes as a function of group and substance. Statistical maps depict the interacting effects of group and substance on amygdala (A) and insula (B) activity pooled across scene valence. Bar plots show parameter estimates extracted from the peak voxels of amygdala and insula analyses as a function of group and substance across valence categories. Similar bar plots were also generated for each valence category to illustrate the similarity of response patterns. Significance stars (†P < 0.10, *P < 0.05, **P < 0.01) indicate results of planned comparisons between placebo and oxytocin administration within the HC group as well as within the BPD group. Error bars indicate standard errors of the mean.

Similar articles

See all similar articles

Cited by 2 PubMed Central articles

References

    1. Andari E., Duhamel J.R., Zalla T., Herbrecht E., Leboyer M., Sirigu A. (2010). Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Proceedings of the National Academy of Science of the United States of America 107(9), 4389–94. - PMC - PubMed
    1. Arntz A., Dietzel R., Dreessen L. (1999). Assumptions in borderline personality disorder: specificity, stability and relationship with etiological factors. Behaviour Research and Therapy 37(6), 545–57. - PubMed
    1. Arntz A., ten Haaf J. (2012). Social cognition in borderline personality disorder: evidence for dichotomous thinking but no evidence for less complex attributions. Behaviour Research and Therapy 50(11), 707–18. - PubMed
    1. Arntz A., Veen G. (2001). Evaluations of others by borderline patients. The Journal of Nervous and Mental Disease 189(8), 513–21. - PubMed
    1. Arntz A., Weertman A., Salet S. (2011). Interpretation bias in Cluster-C and borderline personality disorders. Behaviour Research and Therapy 49(8), 472–81. - PubMed
Feedback