The FASTK family of proteins: emerging regulators of mitochondrial RNA biology

Nucleic Acids Res. 2017 Nov 2;45(19):10941-10947. doi: 10.1093/nar/gkx772.


The FASTK family proteins have recently emerged as key post-transcriptional regulators of mitochondrial gene expression. FASTK, the founding member and its homologs FASTKD1-5 are architecturally related RNA-binding proteins, each having a different function in the regulation of mitochondrial RNA biology, from mRNA processing and maturation to ribosome assembly and translation. In this review, we outline the structure, evolution and function of these FASTK proteins and discuss the individual role that each has in mitochondrial RNA biology. In addition, we highlight the aspects of FASTK research that still require more attention.

Publication types

  • Review

MeSH terms

  • Gene Expression Regulation*
  • Humans
  • Mitochondrial Proteins / genetics*
  • Mitochondrial Proteins / metabolism
  • Protein Serine-Threonine Kinases / genetics*
  • Protein Serine-Threonine Kinases / metabolism
  • RNA / genetics*
  • RNA / metabolism
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • RNA, Mitochondrial
  • RNA-Binding Proteins / genetics*
  • RNA-Binding Proteins / metabolism


  • FASTKD1 protein, human
  • Mitochondrial Proteins
  • RNA, Messenger
  • RNA, Mitochondrial
  • RNA-Binding Proteins
  • TBRG4 protein, human
  • RNA
  • FASTKD2 protein, human
  • FASTKD3 protein, human
  • Protein Serine-Threonine Kinases