alpha-Adrenoceptors and cold-induced vasoconstriction in human finger skin

Am J Physiol. 1988 Nov;255(5 Pt 2):H1000-3. doi: 10.1152/ajpheart.1988.255.5.H1000.


Experiments were designed to determine how cold-induced vasoconstriction is mediated in superficial vessels of human finger skin. alpha-Adrenoceptor antagonists were administered into the finger skin by iontophoresis, and local cooling was applied by a laser-Doppler probe supplied with Peltier elements. Cold-induced vasoconstriction was abolished after administration of the alpha 2-adrenoceptor antagonist rauwolscine but not after the alpha 1-adrenoceptor antagonist doxazosin. The results indicate that vasoconstriction on local cooling in human finger skin is mainly mediated by adrenoceptors of the alpha 2-subtype.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic alpha-Agonists
  • Azepines / pharmacology
  • Cold Temperature*
  • Doxazosin
  • Fingers
  • Humans
  • Male
  • Phenylephrine / pharmacology
  • Prazosin / analogs & derivatives
  • Prazosin / pharmacology
  • Receptors, Adrenergic, alpha / physiology*
  • Regional Blood Flow / drug effects
  • Skin / blood supply*
  • Vasoconstriction*
  • Yohimbine / pharmacology


  • Adrenergic alpha-Agonists
  • Azepines
  • Receptors, Adrenergic, alpha
  • Phenylephrine
  • Yohimbine
  • azepexole
  • Doxazosin
  • Prazosin