Chngpt: Threshold Regression Model Estimation and Inference

BMC Bioinformatics. 2017 Oct 16;18(1):454. doi: 10.1186/s12859-017-1863-x.


Background: Threshold regression models are a diverse set of non-regular regression models that all depend on change points or thresholds. They provide a simple but elegant and interpretable way to model certain kinds of nonlinear relationships between the outcome and a predictor.

Results: The R package chngpt provides both estimation and hypothesis testing functionalities for four common variants of threshold regression models. All allow for adjustment of additional covariates not subjected to thresholding. We demonstrate the consistency of the estimating procedures and the type 1 error rates of the testing procedures by Monte Carlo studies, and illustrate their practical uses using an example from the study of immune response biomarkers in the context of Mother-To-Child-Transmission of HIV-1 viruses.

Conclusion: chngpt makes several unique contributions to the software for threshold regression models and will make these models more accessible to practitioners interested in modeling threshold effects.

Keywords: Change point; Jump-type; Regression kink; Segmented regression model.

MeSH terms

  • HIV Infections / immunology
  • HIV Infections / transmission
  • HIV-1 / immunology
  • Humans
  • Models, Statistical*
  • Monte Carlo Method
  • Regression Analysis
  • Software*
  • Time Factors