Epidemiology and burden of HPV-related disease

Best Pract Res Clin Obstet Gynaecol. 2018 Feb;47:14-26. doi: 10.1016/j.bpobgyn.2017.08.006. Epub 2017 Sep 2.

Abstract

Human papillomavirus (HPV) infection is recognized as one of the major causes of infection-related cancer in both men and women. High-risk HPV types are not only responsible for virtually all cervical cancer cases but also for a fraction of cancers of the vulva, vagina, penis, anus, and head and neck cancers. Furthermore, HPV is also the cause of anogenital warts and recurrent respiratory papillomatosis. Despite the availability of multiple preventative strategies, HPV-related cancer remains a leading cause of morbi-mortality in many parts of the world, particularly in less developed countries. Thus, in this review, we summarize the latest estimates of the global burden of HPV-related diseases, trends, the attributable fraction by HPV types, and the potential preventative fraction.

Keywords: Attributable fraction; Cancer; Human papillomavirus; Papillomavirus vaccines; Prevention; Time trends.

Publication types

  • Review

MeSH terms

  • Age Distribution
  • Anus Neoplasms / epidemiology*
  • Anus Neoplasms / prevention & control
  • Anus Neoplasms / virology
  • Female
  • Global Burden of Disease / statistics & numerical data*
  • Head and Neck Neoplasms / epidemiology*
  • Head and Neck Neoplasms / prevention & control
  • Head and Neck Neoplasms / virology
  • Humans
  • Incidence
  • Male
  • Papillomaviridae
  • Papillomavirus Infections / epidemiology*
  • Papillomavirus Infections / prevention & control
  • Papillomavirus Vaccines
  • Penile Neoplasms / epidemiology*
  • Penile Neoplasms / prevention & control
  • Penile Neoplasms / virology
  • Uterine Cervical Neoplasms / epidemiology*
  • Uterine Cervical Neoplasms / prevention & control
  • Uterine Cervical Neoplasms / virology

Substances

  • Papillomavirus Vaccines