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Comparison of Human Papillomavirus (HPV) Detection in Urine and Cervical Swab Samples Using the HPV GenoArray Diagnostic Assay

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Comparison of Human Papillomavirus (HPV) Detection in Urine and Cervical Swab Samples Using the HPV GenoArray Diagnostic Assay

Pornjarim Nilyanimit et al. PeerJ.

Abstract

Human papillomavirus (HPV) is the leading cause of cervical cancer. Urine-based HPV testing offers a simple and non-invasive method because of its increasing acceptance. A total of 164 pairs of cervical swab and urine samples from Thai women who underwent cervical cancer screening were used for HPV testing with HPV GenoArray Diagnostic Kits. The overall concordance percentage for HPV detection in the cervical swab and urine samples was 65.2%. The HPV genotypes most commonly detected were HPV16 and HPV18. An analysis of the urine samples and a second analysis of the cervical swab samples showed that the differences in the overall HPV detection rate between women with normal and abnormal cytology were not significant (p > 0.05). Urine samples processed with the GenoArray assay is an alternative for women who decline to undergo Pap smear even though it is not ideal as the first-line screening option.

Keywords: Cervical cancer; Genotyping; HPV; Urine.

Conflict of interest statement

The authors declare there are no competing interests.

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Cited by 2 PubMed Central articles

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Grant support

This work was supported by the National Research Council of Thailand, the Research Chair Grant from NSTDA, the Center of Excellence in Clinical Virology (GCE 59-009-30-005) and King Chulalongkorn University, the Centenary Academic Development Project (CU56-HR01), the Ratchadaphiseksomphot Endowment Fund of Chulalongkorn University (RES560530093), Office of Higher Education Commission (NRU 59-002-HR) and Dutsadi Piphat Scholarship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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