Effect of Bariatric Surgery on Thyroid Function in Obese Patients: a Systematic Review and Meta-Analysis

Obes Surg. 2017 Dec;27(12):3292-3305. doi: 10.1007/s11695-017-2965-2.

Abstract

We aimed to make a meta-analysis regarding the effect of bariatric surgery on thyroid function in obese patients. PubMed, EMBASE, CENTRAL, and four Chinese databases were searched for clinical studies. Data were pooled using Review Manager 5.3, and subgroup and sensitivity analyses were performed if necessary and feasible. As a result, 24 articles were included into meta-analysis. Bariatric surgery was associated with significant decrease in TSH, FT3, and T3 levels. However, FT4, T4, and rT3 levels were not significantly changed postoperatively. In addition, bariatric surgery had a favorable effect on overt and subclinical hypothyroid, with reduction of thyroid hormone requirements postoperatively. In conclusion, TSH, FT3, and T3 decrease are expected following bariatric surgery, as well as non-significant change of T4, FT4, and rT3 levels.

Keywords: Bariatric surgery; Meta-analysis; Obesity; Systematic review; Thyroid function.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Bariatric Surgery* / adverse effects
  • Bariatric Surgery* / statistics & numerical data
  • Humans
  • Hypothyroidism / epidemiology
  • Hypothyroidism / etiology
  • Obesity, Morbid / epidemiology
  • Obesity, Morbid / physiopathology
  • Obesity, Morbid / surgery*
  • Postoperative Complications / blood
  • Postoperative Complications / epidemiology
  • Thyroid Function Tests
  • Thyroid Gland / physiopathology*
  • Thyroid Hormones / blood

Substances

  • Thyroid Hormones