Quantitation of Surface Coating on Nanoparticles Using Thermogravimetric Analysis

Methods Mol Biol. 2018;1682:57-63. doi: 10.1007/978-1-4939-7352-1_6.


Nanoparticles are critical components in nanomedicine and nanotherapeutic applications. Some nanoparticles, such as metallic nanoparticles, consist of a surface coating or surface modification to aid in its dispersion and stability. This surface coating may affect the behavior of nanoparticles in a biological environment, thus it is important to measure. Thermogravimetric analysis (TGA) can be used to determine the amount of coating on the surface of the nanoparticle. TGA experiments run under inert atmosphere can also be used to determine residual metal content present in the sample. In this chapter, the TGA technique and experimental method are described.

Keywords: Colloidal metal nanoparticles; Inorganic nanoparticles; Nanoparticles; Surface coating; TGA.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Coated Materials, Biocompatible / chemistry*
  • Nanoparticles / chemistry*
  • Nanotechnology / methods
  • Surface Properties
  • Thermogravimetry / methods*


  • Coated Materials, Biocompatible