The synergism and attenuation effect of Selenium (Se)-enriched Grifola frondosa (Se)-polysaccharide on 5-Fluorouracil (5-Fu) in Heps-bearing mice

Int J Biol Macromol. 2018 Feb;107(Pt B):2211-2216. doi: 10.1016/j.ijbiomac.2017.10.084. Epub 2017 Oct 16.


Previous study revealed that Se-GP11 could exhibited its antitumor activity by improving the immune functions. 5-Fu, as a chemotherapeutic drugs, can kill many immune cells in addition to tumor cells. Accordingly, the enhanced antitumor and reduced toxicity of Se-GP11 on 5-Fu were estimated in this study. The results demonstrated that Se-GP11 could evidently increase the antitumor activity of 5-Fu. Furthermore, Se-GP11 could enhance the immune functions during the tumor inhibition process of 5-Fu for increasing the cytokines secretion (IL-2 and TNF-α) and immune organs weights. In addition, Se-GP11 could reduce the toxicity of 5-Fu on liver by improving the hematological and biochemical parameters and up-regulating the SOD activities and down-regulating the MDA levels. Taken together, the results indicated that Se-GP11 may develop as an auxiliary preparation to chemical antitumor drugs.

Keywords: Attenuation; Grifola frondosa; Polysaccharide; Selenium-enriched; Synergism.

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Body Weight / drug effects
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Drug Synergism
  • Female
  • Fluorouracil / pharmacology
  • Fluorouracil / therapeutic use*
  • Grifola / chemistry*
  • Interleukin-2 / blood
  • Liver Neoplasms / drug therapy
  • Liver Neoplasms / pathology
  • Malondialdehyde / metabolism
  • Mice, Inbred ICR
  • Organ Size / drug effects
  • Organ Specificity
  • Polysaccharides / pharmacology
  • Polysaccharides / therapeutic use*
  • Selenium / pharmacology
  • Selenium / therapeutic use*
  • Superoxide Dismutase / metabolism
  • Tumor Necrosis Factor-alpha / blood


  • Antineoplastic Agents
  • Interleukin-2
  • Polysaccharides
  • Tumor Necrosis Factor-alpha
  • Malondialdehyde
  • Superoxide Dismutase
  • Selenium
  • Fluorouracil