In Vivo Characterizations of the Immune Properties of Sericin: An Ancient Material with Emerging Value in Biomedical Applications

Zhanying Jiao; Yu Song; Yang Jin; Cheng Zhang; Dong Peng; Zhenzhen Chen; Panpan Chang; Subhas C Kundu; Guobin Wang; Zheng Wang; Lin Wang

doi:10.1002/mabi.201700229

In Vivo Characterizations of the Immune Properties of Sericin: An Ancient Material with Emerging Value in Biomedical Applications

Macromol Biosci. 2017 Dec;17(12). doi: 10.1002/mabi.201700229. Epub 2017 Oct 17.

Authors

Zhanying Jiao¹, Yu Song¹, Yang Jin², Cheng Zhang¹, Dong Peng¹, Zhenzhen Chen¹, Panpan Chang³, Subhas C Kundu⁴, Guobin Wang⁵, Zheng Wang^{1

5}, Lin Wang^{1

6}

Affiliations

¹ Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
² Department of Respiration, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
³ Medical Research Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
⁴ 3Bs Research Group, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, AvePark, 4805-017, Barco, Guimaraes, Portugal.
⁵ Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
⁶ Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

PMID: 29045024
DOI: 10.1002/mabi.201700229

Abstract

The biosafety of sericin remains controversial. The misunderstanding regarding sericin causing adverse biological responses have been clarified by extensively reviewing relevant literatures and experimentally demonstrating that sericin exhibits mild inflammatory responses, negligible allergenicity, and low immunogenicity in vivo. This study supports that sericin is biosafe as a natural biomaterial.

Keywords: allergenicity; immunogenicity; inflammatory; sericin; silk.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adaptive Immunity / drug effects
Animals
Biocompatible Materials / adverse effects*
Bombyx / genetics
Drug Hypersensitivity / etiology
Fibroins / immunology
Fibroins / pharmacology
Immunity, Innate / drug effects
Inflammation / chemically induced
Male
Materials Testing
Mice
Mice, Inbred BALB C
Mutation
RAW 264.7 Cells
Sericins / adverse effects
Sericins / immunology*
Sericins / pharmacology*

Substances

Biocompatible Materials
Sericins
Fibroins