Objective: To assess the association between serum 25-hydroxyvitamin D [25(OH)D] levels at birth and bronchopulmonary dysplasia (BPD) in preterm infants.
Methods: This study recruited preterm infants with gestational age of below 34 weeks who were born between January 2014 and December 2016. These preterm infants were classified into two groups: BPD and control. The association between serum 25(OH)D levels at birth and BPD was analyzed.
Results: Serum 25(OH)D levels in the BPD group was significantly lower than those in the control group [(37±17 nmol/L vs 47±20 nmol/L; P<0.05), and the rate of vitamin D deficiency was significantly higher than those in the control group (90.2% vs 74.0%; P<0.05). The level of serum 25(OH)D was negatively correlated with the incidence of BPD (r=-0.201, P=0.001).
Conclusions: Vitamin D deficiency at birth may be associated with BPD in preterm infants, but need to be further studied by multivariate analysis.
目的: 分析早产儿出生时血清25-羟维生素D [25（OH）D]水平与支气管肺发育不良（BPD）的关系。
方法: 选取2014年1月至2016年12月入住NICU、出生胎龄 < 34周的早产儿，按是否患BPD分为BPD组（41例）和对照组（219例），分析25（OH）D水平与BPD的关系。
结果: BPD组血清25（OH）D水平显著低于对照组（37±17 nmol/L vs 47±20 nmol/L；P < 0.05）；维生素D缺乏率显著高于对照组（90.2% vs 74.0%，P < 0.05）。血清25（OH）D水平与BPD发生率呈负相关（r=-0.201，P=0.001）。
结论: 早产儿维生素D缺乏可能与BPD发病有关，但需多因素分析进一步证实。