1,3,5-Triazines: A promising scaffold for anticancer drugs development

Abstract

This review covering literature reports from the beginning of this century to 2016 describes the synthetic pathways, the antitumor activity, the structure-activity relationship and, whenever reported, the possible mechanism of action of 1,3,5-triazine derivatives as well as of their hetero-fused compounds. Many 1,3,5-triazine derivatives, both uncondensed and hetero-fused, have shown remarkable antitumor activities and some of them reached clinical development.

Keywords: 1,3,5-Triazines; Antitumor activity; Disubstituted 1,3,5-triazines; Heterofused 1,3,5-triazines; Nitrogen heterocycles; Trisubstituted 1,3,5-triazines.