Effect of Intravenous Fentanyl on Ticagrelor Absorption and Platelet Inhibition Among Patients Undergoing Percutaneous Coronary Intervention: The PACIFY Randomized Clinical Trial (Platelet Aggregation With Ticagrelor Inhibition and Fentanyl)

Circulation. 2018 Jan 16;137(3):307-309. doi: 10.1161/CIRCULATIONAHA.117.031678. Epub 2017 Oct 18.

Authors

John W McEvoy^{1

2

3}, Khalil Ibrahim², Thomas S Kickler⁴, William A Clarke⁴, Rani K Hasan², Matthew J Czarny², Ali R Keramati², Rakesh R Goli⁵, Travis P Gratton⁵, Jeffrey A Brinker², Matthews Chacko², Chao-Wei Hwang², Peter V Johnston², Julie M Miller², Jeffrey C Trost², William R Herzog², Roger S Blumenthal^{6

2}, David R Thiemann², Jon R Resar², Steven P Schulman²

Affiliations

¹ Ciccarone Center for the Prevention of Heart Disease (J.W.M., R.S.B.) jmcevoy1@jhmi.edu.
² Division of Cardiology, Department of Medicine (J.W.M., K.I., R.K.H., M.J.C., A.R.K., J.A.B., M.C., C.-W.H., P.V.J., J.M.M., J.C.T., W.R.H., R.S.B., D.R.T., J.R.R., S.P.S.).
³ Johns Hopkins University School of Medicine, Baltimore, MD. Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (J.W.M.).
⁴ Department of Pathology (T.S.K., W.A.C.).
⁵ Department of Medicine (R.R.G., T.P.G.).
⁶ Ciccarone Center for the Prevention of Heart Disease (J.W.M., R.S.B.).

PMID: 29046319
DOI: 10.1161/CIRCULATIONAHA.117.031678

No abstract available

Keywords: blood platelets; fentanyl; percutaneous coronary intervention; ticagrelor.

Publication types

Letter
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Administration, Intravenous
Administration, Oral
Analgesics, Opioid / administration & dosage*
Analgesics, Opioid / adverse effects
Baltimore
Blood Platelets / drug effects*
Blood Platelets / metabolism
Drug Interactions
Drug Monitoring / methods
Female
Fentanyl / administration & dosage*
Fentanyl / adverse effects
Gastrointestinal Absorption / drug effects*
Humans
Male
Middle Aged
Percutaneous Coronary Intervention* / adverse effects
Platelet Aggregation / drug effects
Platelet Aggregation Inhibitors / administration & dosage*
Platelet Aggregation Inhibitors / adverse effects
Platelet Aggregation Inhibitors / blood
Platelet Function Tests
Purinergic P2Y Receptor Antagonists / administration & dosage*
Purinergic P2Y Receptor Antagonists / adverse effects
Purinergic P2Y Receptor Antagonists / blood
Receptors, Purinergic P2Y12 / blood
Receptors, Purinergic P2Y12 / drug effects
Risk Assessment
Ticagrelor / administration & dosage*
Ticagrelor / adverse effects
Ticagrelor / blood
Time Factors
Treatment Outcome

Substances

Analgesics, Opioid
P2RY12 protein, human
Platelet Aggregation Inhibitors
Purinergic P2Y Receptor Antagonists
Receptors, Purinergic P2Y12
Ticagrelor
Fentanyl

Associated data

ClinicalTrials.gov/NCT02683707