Neuroleptic binding to human brain receptors: relation to clinical effects

Ann N Y Acad Sci. 1988;537:435-42. doi: 10.1111/j.1749-6632.1988.tb42125.x.

Abstract

Table 2 summarizes the potential clinical consequences of neurotransmitter receptor blockade by neuroleptics. These pharmacological effects of neuroleptics at receptors in brain and elsewhere in the body are likely responsible for therapeutic and certain adverse effects as well as some drug-drug interactions. Data presented here should allow the physician a rational basis for selecting neuroleptics to minimize these unwanted effects in patients.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antipsychotic Agents / adverse effects
  • Antipsychotic Agents / metabolism*
  • Antipsychotic Agents / pharmacology
  • Brain / drug effects
  • Brain / metabolism*
  • Humans
  • Receptors, Adrenergic, alpha / drug effects
  • Receptors, Adrenergic, alpha / metabolism
  • Receptors, Dopamine / drug effects
  • Receptors, Dopamine / metabolism
  • Receptors, Dopamine D2
  • Receptors, Histamine / drug effects
  • Receptors, Histamine / metabolism
  • Receptors, Muscarinic / drug effects
  • Receptors, Muscarinic / metabolism
  • Receptors, Neurotransmitter / drug effects
  • Receptors, Neurotransmitter / metabolism*
  • Receptors, Serotonin / drug effects
  • Receptors, Serotonin / metabolism

Substances

  • Antipsychotic Agents
  • Receptors, Adrenergic, alpha
  • Receptors, Dopamine
  • Receptors, Dopamine D2
  • Receptors, Histamine
  • Receptors, Muscarinic
  • Receptors, Neurotransmitter
  • Receptors, Serotonin