MmpS5/MmpL5 as an efflux pump in Mycobacterium species

Tuberculosis (Edinb). 2017 Dec;107:13-19. doi: 10.1016/j.tube.2017.08.001. Epub 2017 Aug 4.

Abstract

Tuberculosis remains an important cause of morbidity and mortality throughout the world, amplified by the expansion of antibiotic resistance. Increasing active efflux of the antibiotic is one of the several strategies used by bacteria to resist to antibiotics. After showing the importance of the RND superfamily of efflux pumps in drug resistance, this review focuses on the protein MmpL5, a transmembrane transporter of Mycobacterium. These exporters should be involved in the variety of roles in bacterial cells, including expelling various drugs. The mutation in the transcriptional regulator, linked to the upregulation of MmpL5 can lead to resistance of antibiotics. The study of these mechanisms should be considered in order to improve the treatment of tuberculosis.

Keywords: Drug resistance mechanism; Efflux pump; MmpL; Mycobacterium.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / metabolism*
  • Antitubercular Agents / therapeutic use
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Drug Resistance, Bacterial* / genetics
  • Genotype
  • Humans
  • Membrane Transport Proteins / genetics
  • Membrane Transport Proteins / metabolism*
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / genetics
  • Mycobacterium tuberculosis / metabolism*
  • Tuberculosis / diagnosis
  • Tuberculosis / drug therapy
  • Tuberculosis / epidemiology
  • Tuberculosis / microbiology*

Substances

  • Antitubercular Agents
  • Bacterial Proteins
  • Membrane Transport Proteins