[The protective effect of pantothenic acid derivatives and changes in the system of acetyl CoA metabolism in acute ethanol poisoning]

Farmakol Toksikol. Sep-Oct 1988;51(5):82-6.
[Article in Russian]

Abstract

Calcium pantothenate (CaP), calcium 4'-phosphopantothenate (CaPP), pantethine, panthenol, sulfopantetheine and CoA decrease acute toxicity of acetaldehyde in mice. All studied compounds diminish duration of the narcotic action of ethanol--ET (3.5 g/kg intraperitoneally) in mice and rats. In the latter this effect is realized at the expense of "long sleeping" and "middle sleeping" animals. CaP (150 mg/kg subcutaneously) and CaPP (100 mg/kg subcutaneously) prevent hypothermia and a decrease of oxygen consumption in rats induced by ET administration. Combined administration of ET, CaP and CaPP leads to a characteristic increase of acid-soluble CoA fractions in the rat liver and a relative decrease of acetyl CoA synthetase and N-acetyltransferase reactions. The antitoxic effect of preparations of pantothenic acid is not mediated by CoA-dependent reactions of detoxication, but most probably is due to intensification of ET oxidation and perhaps to its elimination from the organism.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Acetaldehyde / poisoning
  • Acetate-CoA Ligase / metabolism
  • Acetyl Coenzyme A / biosynthesis*
  • Acetylation
  • Alcoholic Intoxication / drug therapy*
  • Alcoholic Intoxication / enzymology
  • Animals
  • Arylamine N-Acetyltransferase / metabolism
  • Drug Evaluation, Preclinical
  • Enzyme Induction / drug effects
  • Female
  • Liver / drug effects
  • Liver / enzymology
  • Male
  • Mice
  • Pantothenic Acid / analogs & derivatives*
  • Pantothenic Acid / therapeutic use
  • Rats

Substances

  • Pantothenic Acid
  • Acetyl Coenzyme A
  • Arylamine N-Acetyltransferase
  • Acetate-CoA Ligase
  • Acetaldehyde