Curcumin, hemostasis, thrombosis, and coagulation

J Cell Physiol. 2018 Jun;233(6):4497-4511. doi: 10.1002/jcp.26249. Epub 2017 Dec 26.


Atherothrombotic cardiovascular disease is a major cause of mortality throughout the world. Platelet activation and aggregation play a central role in hemostasis and thrombosis. Herbal medicines have been traditionally used in the management of cardiovascular disease and can help in modifying its progression, particularly in hemostasis and the coagulation process, as well as altering platelet function tests and some coagulation parameters. Curcumin is a polyphenol derived from the Curcuma longa plant and has been used extensively in complementary and alternative medicine, as it is nontoxic and safe with various therapeutic properties. Modern scientific research has demonstrated its anti-inflammatory, antioxidant, anti-carcinogenic, antithrombotic, and cardiovascular protective effects. The present study reviewed previous studies in the literature, which support the positive activity of curcumin in hemostasis, anticoagulation, and fibrinolysis. We also presented molecular mechanisms associated with the antiplatelet and anticoagulant activities of curcumin and potential implications for the treatment of cardiovascular disease.

Keywords: Curcuma longa; Curcumin; anticoagulant agent; antithrombotic agents; hemostasis.

Publication types

  • Review

MeSH terms

  • Animals
  • Anticoagulants / therapeutic use*
  • Blood Coagulation / drug effects
  • Blood Platelets / drug effects
  • Blood Platelets / metabolism
  • Cell Adhesion Molecules / metabolism
  • Curcumin / therapeutic use*
  • Fibrinolysis / drug effects
  • Fibrinolytic Agents / therapeutic use*
  • Hemostasis / drug effects*
  • Hemostatics / therapeutic use*
  • Humans
  • Leukocytes / drug effects
  • Leukocytes / metabolism
  • Platelet Activation / drug effects
  • Platelet Aggregation Inhibitors / therapeutic use
  • Thrombosis / blood
  • Thrombosis / prevention & control*


  • Anticoagulants
  • Cell Adhesion Molecules
  • Fibrinolytic Agents
  • Hemostatics
  • Platelet Aggregation Inhibitors
  • Curcumin