Relationship between chronic kidney disease without diabetes mellitus and components of frailty in community-dwelling Japanese older adults

Geriatr Gerontol Int. 2018 Feb;18(2):286-292. doi: 10.1111/ggi.13180. Epub 2017 Oct 20.


Aim: To evaluate the relationship between kidney function without diabetes and components of the frailty phenotype in community-dwelling Japanese older adults.

Methods: Participants were 8343 residents who completed baseline assessments, classified into four categories according to eGFR. Frailty status was defined using five criteria: (i) slow gait speed; (ii) muscle weakness; (iii) low physical activity; (iv) exhaustion; and (v) unintentional weight loss.

Results: After multivariate adjustment, participants with the lowest kidney function were at higher risk of frailty (OR 1.57, 95% CI 1.02-3.50) than those with normal kidney function. In addition, after adjustment for multiple confounders, estimated glomerular filtration rate <30 was associated with a greater risk of the individual frailty components of weight loss (OR 2.14, 95% CI 1.11-4.12), low physical activity (OR 1.35, 95% CI, 1.01-2.54) and slowness (OR 1.82, 95% CI 1.36-3.77) compared with estimated glomerular filtration rate ≥60.

Conclusions: Lower kidney function was associated with a higher risk of weight loss, low physical activity and slowness among community-dwelling Japanese older adults. Geriatr Gerontol Int 2018; 18: 286-292.

Keywords: chronic kidney disease; estimated glomerular filtration rate; frail; older adults.

MeSH terms

  • Aged
  • Diabetes Mellitus / epidemiology
  • Frailty / epidemiology*
  • Humans
  • Independent Living
  • Japan / epidemiology
  • Renal Insufficiency, Chronic / epidemiology*