Spt6 Gets in the Way of Polycomb to Promote ESC Pluripotency

Mol Cell. 2017 Oct 19;68(2):263-264. doi: 10.1016/j.molcel.2017.10.005.


Despite expressing high levels of Polycomb group proteins, embryonic stem cells (ESCs) are refractory to H3K27 trimethylation, notably at super-enhancers regulating key pluripotency genes. In this issue of Molecular Cell, Wang et al. (2017) report that the histone chaperone Spt6 prevents H3K27 trimethylation of key ESC super-enhancers.

Publication types

  • Comment

MeSH terms

  • Cell Line
  • Drosophila Proteins*
  • Histones
  • Peptide Elongation Factors*
  • Polycomb-Group Proteins


  • Drosophila Proteins
  • Histones
  • Peptide Elongation Factors
  • Polycomb-Group Proteins