Mechanisms driving the ageing heart

Exp Gerontol. 2018 Aug:109:5-15. doi: 10.1016/j.exger.2017.10.015. Epub 2017 Oct 18.


Cardiovascular disease (CVD) is the leading cause of death globally. One of the main risk factors for CVD is age, however the biological processes that occur in the heart during ageing are poorly understood. It is therefore important to understand the fundamental mechanisms driving heart ageing to enable the development of preventions and treatments targeting these processes. Cellular senescence is often described as the irreversible cell-cycle arrest which occurs in somatic cells. Emerging evidence suggests that cellular senescence plays a key role in heart ageing, however the cell-types involved and the underlying mechanisms are not yet elucidated. In this review we discuss the current understanding of how mechanisms known to contribute to senescence impact on heart ageing and CVD. Finally, we evaluate recent data suggesting that targeting senescent cells may be a viable therapy to counteract the ageing of the heart.

Keywords: DNA damage response; Mitochondria; Reactive oxygen species; Senescence; Telomeres.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / physiology*
  • Animals
  • Cardiovascular Diseases / etiology
  • Cellular Senescence / physiology*
  • DNA Damage
  • DNA Repair
  • Heart / physiology*
  • Humans
  • Mitochondria / physiology
  • Reactive Oxygen Species / metabolism
  • Telomere


  • Reactive Oxygen Species