Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery

Front Neuroendocrinol. 2018 Oct;51:14-24. doi: 10.1016/j.yfrne.2017.10.004. Epub 2017 Oct 18.

Abstract

Oxytocin (OT) and arginine-vasopressin (AVP) act in the brain to regulate social cognition/social behavior and in the periphery to influence a variety of physiological processes. Although the chemical structures of OT and AVP as well as their receptors are quite similar, OT and AVP can have distinct or even opposing actions. Here, we review the increasing body of evidence that exogenously administered and endogenously released OT and AVP can activate each other's canonical receptors (i.e., cross-talk) and examine the possibility that receptor cross-talk following the synaptic and non-synaptic release of OT and AVP contributes to their distinct roles in the brain and periphery. Understanding the consequences of cross-talk between OT and AVP receptors will be important in identifying how these peptides control social cognition and behavior and for the development of drugs to treat a variety of psychiatric disorders.

Keywords: Autism spectrum disorder; G protein-coupled receptors; Intranasal administration; Pair bonding; Prosocial behavior; Social behavior; Social cognition; Social communication; Social recognition; Social reward.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Arginine Vasopressin / metabolism*
  • Arginine Vasopressin / pharmacology
  • Female
  • Humans
  • Male
  • Mental Disorders / drug therapy
  • Mental Disorders / metabolism*
  • Oxytocin / metabolism*
  • Oxytocin / pharmacology
  • Receptors, Oxytocin / drug effects
  • Receptors, Oxytocin / metabolism*
  • Receptors, Vasopressin / drug effects
  • Receptors, Vasopressin / metabolism*
  • Social Behavior*

Substances

  • Receptors, Oxytocin
  • Receptors, Vasopressin
  • Arginine Vasopressin
  • Oxytocin