Positive end-expiratory pressure adjusted for intra-abdominal pressure - A pilot study

Abstract

Purpose: Intra-abdominal hypertension (IAH) is associated with impaired respiratory function. Animal data suggest that positive end-expiratory pressure (PEEP) levels adjusted to intra-abdominal pressure (IAP) levels may counteract IAH-induced respiratory dysfunction. In this pilot study, our aim was to assess whether PEEP adjusted for IAP can be applied safely in patients with IAH.

Materials and methods: We included patients on mechanical ventilation and with IAH. Patients were excluded with severe cardiovascular dysfunction or severe hypoxemia or if the patient was in imminent danger of dying. Following a recruitment manoeuvre, the following PEEP levels were randomly applied: PEEP of 5cmH₂O (baseline), PEEP=50% of IAP, and PEEP=100% of IAP. After a 30min equilibration period we measured arterial blood gases and cardio-respiratory parameters.

Results: Fifteen patients were enrolled. Six (41%) patients did not tolerate PEEP=100% IAP due to hypoxemia, hypotension or endotracheal cuff leak. PaO₂/FiO₂ ratios were 234 (68), 271 (99), and 329 (107) respectively. The differences were significant (p=0.009) only between baseline and PEEP=100% IAP.

Conclusions: PEEP=100% of IAP was not well-tolerated and only marginally improved oxygenation in ventilated patients with IAH.

Keywords: Abdominal compartment syndrome; Airway pressures; Cuff leak; Intra-abdominal hypertension; Intra-abdominal pressure; Positive end-expiratory pressure; Respiratory compliance.