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. 2018 Mar;27(3):802-809.
doi: 10.1002/pon.4571. Epub 2017 Nov 21.

Cognition, quality-of-life, and symptom clusters in breast cancer: Using Bayesian networks to elucidate complex relationships

Selene Xu  1 , Wesley Thompson  2 , Sonia Ancoli-Israel  2 , Lianqi Liu  2 , Barton Palmer  2   3 , Loki Natarajan  3   4
Affiliations

Cognition, quality-of-life, and symptom clusters in breast cancer: Using Bayesian networks to elucidate complex relationships

Selene Xu et al. Psychooncology. 2018 Mar.

Abstract

Objective: Breast cancer patients frequently complain of cognitive dysfunction during chemotherapy. Patients also report experiencing a cluster of sleep problems, fatigue, and depressive symptoms during chemotherapy. We aimed to understand the complex dynamic interrelationships of depression, fatigue, and sleep to ultimately elucidate their role in cognitive performance and quality of life amongst breast cancer survivors undergoing chemotherapy treatment.

Methods: Our study sample comprised 74 newly diagnosed stage I to III breast cancer patients scheduled to receive chemotherapy. An objective neuropsychological test battery and self-reported fatigue, mood, sleep quality, and quality of life were collected at 3 time points: before the start of chemotherapy (baseline: BL), at the end of cycle 4 chemotherapy (C4), and 1 year after the start of chemotherapy (Y1). We applied novel Bayesian network methods to investigate the role of sleep/fatigue/mood on cognition and quality of life prior to, during, and after chemotherapy.

Results: The fitted network exhibited strong direct and indirect links between symptoms, cognitive performance, and quality of life. The only symptom directly linked to cognitive performance was C4 sleep quality; at C4, fatigue was directly linked to sleep and thus indirectly influenced cognitive performance. Mood strongly influenced concurrent quality of life at C4 and Y1. Regression estimates indicated that worse sleep quality, fatigue, and mood were negatively associated with cognitive performance or quality of life.

Conclusions: The Bayesian network identified local structure (eg, fatigue-mood-QoL or sleep-cognition) and possible intervention targets (eg, a sleep intervention to reduce cognitive complaints during chemotherapy).

Keywords: Bayesian network; breast cancer; cognitive performance; fatigue; mood; oncology; quality of life; sleep.

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Figures

FIGURE 1
FIGURE 1
Bayesian network of symptoms and outcomes before (BL), during (C4), and after chemotherapy (Y1) amongst breast cancer patients. The circles represent variables, and arrows codify dependencies between variables. The colors and number suffixes represent the 3 time periods: green, 0 = BL; red, 1 = C4; gray, 2: Y1
See this image and copyright information in PMC

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References

    1. Sanford SD, Beaumont JL, Butt Z, Sweet JJ, Cella D, Wagner LI. Prospective longitudinal evaluation of a symptom cluster in breast cancer. J Pain Symptom Manage. 2014;47(4):721–730. - PubMed
    1. Wu HS, Harden JK. Symptom burden and quality of life in survivorship: a review of the literature. Cancer Nurs. 2015;38(1):E29–E54. - PubMed
    1. Guidelines NCCN. Cancer-related fatigue v.1.2013. 2013
    1. Ancoli-Israel S, Liu L, Marler MR, et al. Fatigue, sleep, and circadian rhythms prior to chemotherapy for breast cancer. Support Care Cancer. 2006;14(3):201–209. - PMC - PubMed
    1. Beck SL, Berger AM, Barsevick AM, Wong B, Stewart KA, Dudley WN. Sleep quality after initial chemotherapy for breast cancer. Support Care Cancer. 2010;18(6):679–689. - PMC - PubMed

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