Evaluation of the antioxidant impact of ginger-based kombucha on the murine breast cancer model

J Complement Integr Med. 2017 Oct 21;15(1):/j/jcim.2018.15.issue-1/jcim-2017-0071/jcim-2017-0071.xml. doi: 10.1515/jcim-2017-0071.

Abstract

Background Abnormal metabolism is a common event in cancerous cells. For example, the increase of reactive oxygen species (ROS) production, particularly due to aerobic respiration during invasive stage, results in cancer progression. Herein, the impact of kombucha tea prepared from ginger on the alteration of antioxidant agents was assessed in the breast cancer animal model. Methods Two types of kombucha tea with or without ginger were administered to BALB/c mice before and after tumor challenge. Superoxide dismutase (SOD), catalase, glutathione (GSH) and malondialdehyde (MDA) were evaluated in tumor, liver and kidney. Results Administration of kombucha ginger tea significantly decreased catalase activity as well as GSH and MDA level in tumor homogenate (p<0.001). A significant decrease in SOD activity and increase in MDA quantity was determined in the kidney which had received kombucha ginger tea (p<0.01). Conclusions The consumption of kombucha prepared from ginger could exert minor antioxidant impacts by balancing multi antioxidant factors in different tissues in the breast cancer models.

Keywords: breast cancer; ginger; kombucha; oxidative stress; probiotic.

MeSH terms

  • Animals
  • Antioxidants / administration & dosage*
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / genetics
  • Breast Neoplasms / metabolism
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Female
  • Ginger / chemistry*
  • Glutathione / metabolism
  • Humans
  • Kidney / drug effects
  • Kidney / metabolism
  • Liver / drug effects
  • Liver / metabolism
  • Malondialdehyde / metabolism
  • Mice
  • Mice, Inbred BALB C
  • Oxidative Stress / drug effects
  • Plant Extracts / administration & dosage*
  • Reactive Oxygen Species / metabolism
  • Superoxide Dismutase / metabolism

Substances

  • Antioxidants
  • Plant Extracts
  • Reactive Oxygen Species
  • Malondialdehyde
  • Superoxide Dismutase
  • Glutathione