An immunocytochemical comparison of Müller cells and astrocytes in the cat retina

Exp Eye Res. 1988 Dec;47(6):839-53. doi: 10.1016/0014-4835(88)90067-x.


Immunocytochemical localization, at the light and electron microscopic levels, of five different known glial proteins was used to compare Müller cells with astrocytes in the adult cat retina. Retina from two different areas of the eye was examined. A region of retina on the border of the optic nerve was used because of its large population of astrocytes, and a region away from the optic nerve was used to examine Müller cells (astrocytes are sparse in this region). Antibodies to cellular retinaldehyde binding protein and glutamine synthetase labeled the Müller cells but not the astrocytes, while labeling with anti-carbonic anhydrase C, anti-alpha crystallin and anti-glial fibrillary acidic protein was found in both Müller cells and astrocytes.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Astrocytes / cytology*
  • Carbonic Anhydrases / analysis
  • Carrier Proteins / analysis
  • Cats
  • Crystallins / analysis
  • Glial Fibrillary Acidic Protein / analysis
  • Glutamate-Ammonia Ligase / analysis
  • Immunoblotting
  • Microscopy, Electron
  • Optic Disk / analysis
  • Optic Disk / ultrastructure
  • Retina / cytology*
  • Retinaldehyde / analysis


  • 11-cis-retinal-binding protein
  • Carrier Proteins
  • Crystallins
  • Glial Fibrillary Acidic Protein
  • Carbonic Anhydrases
  • Glutamate-Ammonia Ligase
  • Retinaldehyde