The impact of cellular metabolism on chromatin dynamics and epigenetics

Nat Cell Biol. 2017 Nov;19(11):1298-1306. doi: 10.1038/ncb3629. Epub 2017 Oct 23.


The substrates used to modify nucleic acids and chromatin are affected by nutrient availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a fundamental component of chromatin status and thereby of genome regulation. Here we describe the biochemical and genetic principles of how metabolism can influence chromatin biology and epigenetics, discuss the functional roles of this interplay in developmental and cancer biology, and present future directions in this rapidly emerging area.

Publication types

  • Review

MeSH terms

  • Animals
  • Chromatin / genetics*
  • Epigenesis, Genetic / genetics*
  • Epigenomics / methods
  • Humans
  • Metabolic Networks and Pathways / genetics*
  • Neoplasms / genetics


  • Chromatin