Stimulation of NMDA receptors induces proteolysis of spectrin in hippocampus

Brain Res. 1988 Sep 13;460(1):189-94. doi: 10.1016/0006-8993(88)91222-x.

Abstract

Stimulation of N-methyl-D-aspartate (NMDA) receptors was found to induce proteolysis of brain spectrin in hippocampal slices. The effect was dependent upon extracellular calcium, blocked by the antagonist 2-amino-5-phosphonovalerate (AP5), and was not reproduced by potassium-induced depolarization. These results are consistent with the hypothesis that the involvement of NMDA receptors in plasticity and excitotoxicity is at least partially mediated by calcium-activated proteolysis of cytoskeletal proteins.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 2-Amino-5-phosphonovalerate
  • Animals
  • Anticonvulsants / pharmacology
  • Aspartic Acid / analogs & derivatives*
  • Aspartic Acid / pharmacology
  • Calcium Chloride / pharmacology
  • Evoked Potentials / drug effects
  • Hippocampus / drug effects
  • Hippocampus / metabolism*
  • Hydrolysis
  • In Vitro Techniques
  • N-Methylaspartate
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter / drug effects
  • Receptors, Neurotransmitter / physiology*
  • Spectrin / metabolism*
  • Valine / analogs & derivatives
  • Valine / pharmacology

Substances

  • Anticonvulsants
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter
  • Spectrin
  • Aspartic Acid
  • N-Methylaspartate
  • 2-Amino-5-phosphonovalerate
  • Valine
  • Calcium Chloride