Abstract
Stimulation of N-methyl-D-aspartate (NMDA) receptors was found to induce proteolysis of brain spectrin in hippocampal slices. The effect was dependent upon extracellular calcium, blocked by the antagonist 2-amino-5-phosphonovalerate (AP5), and was not reproduced by potassium-induced depolarization. These results are consistent with the hypothesis that the involvement of NMDA receptors in plasticity and excitotoxicity is at least partially mediated by calcium-activated proteolysis of cytoskeletal proteins.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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2-Amino-5-phosphonovalerate
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Animals
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Anticonvulsants / pharmacology
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Aspartic Acid / analogs & derivatives*
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Aspartic Acid / pharmacology
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Calcium Chloride / pharmacology
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Evoked Potentials / drug effects
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Hippocampus / drug effects
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Hippocampus / metabolism*
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Hydrolysis
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In Vitro Techniques
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N-Methylaspartate
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Receptors, N-Methyl-D-Aspartate
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Receptors, Neurotransmitter / drug effects
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Receptors, Neurotransmitter / physiology*
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Spectrin / metabolism*
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Valine / analogs & derivatives
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Valine / pharmacology
Substances
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Anticonvulsants
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Receptors, N-Methyl-D-Aspartate
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Receptors, Neurotransmitter
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Spectrin
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Aspartic Acid
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N-Methylaspartate
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2-Amino-5-phosphonovalerate
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Valine
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Calcium Chloride