Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil

Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(5):695-700. doi: 10.1016/0278-5846(88)90014-0.


1. Modafinil, a putative central alpha 1 adrenergic agonist, was tested in idiopathic hypersomnia and narcolepsy. 2. Sleep attacks and drowsiness were significantly decreased in 83% of 18 hypersomniac subjects and 71% of 24 narcoleptics. 3. When cataplectic episodes were not totally suppressed the association of a low dose of Clomipramine was successful in improving them. 4. Modafinil, used for at least 3 years in some patients, produces, in most cases, no peripheric sides effects, does not disturb night sleep and is never responsible of tolerance of drug dependence.

MeSH terms

  • Adrenergic alpha-Agonists / therapeutic use*
  • Adult
  • Benzhydryl Compounds / therapeutic use*
  • Disorders of Excessive Somnolence / drug therapy*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Modafinil
  • Narcolepsy / drug therapy*
  • Sleep / drug effects
  • Sleep Wake Disorders / drug therapy*


  • Adrenergic alpha-Agonists
  • Benzhydryl Compounds
  • Modafinil