Fucoidans Stimulate Immune Reaction and Suppress Cancer Growth

Anticancer Res. 2017 Nov;37(11):6041-6046. doi: 10.21873/anticanres.12051.

Abstract

Background/aim: Fucoidans are gaining popularity as natural immunomodulators. The aim of this study was to compare the immunological activities or both purified samples and commercially available mixtures containing fucoidan.

Materials and methods: We evaluated the effects of various samples on phagocytosis, mitogenic response, natural killer (NK) activity, antibody formation and inhibition of breast cancer growth.

Results: We found significant immunostimulating activity, but the strength of these effects was different among individual samples.

Conclusion: Fucoidans have strong immunostimulating potential, including inhibition of cancer, with isolated samples offering better activity than commercial mixtures.

Keywords: Natural immunity; cancer; phagocytosis; polysaccharide.

MeSH terms

  • Adjuvants, Immunologic / pharmacology
  • Animals
  • Antineoplastic Agents / pharmacology
  • Apoptosis / drug effects
  • Cell Proliferation / drug effects
  • Cells, Cultured
  • Female
  • Immunologic Factors
  • Inflammation / immunology
  • Inflammation / pathology
  • Inflammation / prevention & control*
  • Killer Cells, Natural / drug effects
  • Killer Cells, Natural / immunology*
  • Killer Cells, Natural / pathology
  • Macrophages / drug effects
  • Macrophages / immunology*
  • Macrophages / pathology
  • Mammary Neoplasms, Animal / immunology
  • Mammary Neoplasms, Animal / pathology
  • Mammary Neoplasms, Animal / prevention & control*
  • Mice
  • Mice, Inbred BALB C
  • Phagocytosis / drug effects
  • Polysaccharides / pharmacology*
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / pathology

Substances

  • Adjuvants, Immunologic
  • Antineoplastic Agents
  • Immunologic Factors
  • Polysaccharides
  • fucoidan