Comparative Effects of Platelet-Rich Plasma, Platelet Lysate, and Fetal Calf Serum on Mesenchymal Stem Cells

Bull Exp Biol Med. 2017 Oct;163(6):757-760. doi: 10.1007/s10517-017-3897-5. Epub 2017 Oct 24.


We studied the effects of human platelet-rich plasma and platelet lysate on proliferation, migration, and colony-forming properties of rat mesenchymal stem cells. Platelet-rich plasma and platelet lysate stimulated the proliferation, migration, and colony formation of mesenchymal stem cells. A real-time study showed that platelet-rich plasma produces the most potent stimulatory effect, while both platelet-rich plasma and platelet lysate stimulated migration of cells.

Keywords: mesenchymal stem cells; migration; platelet lysate; platelet-rich plasma; proliferation.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Blood Platelets / chemistry*
  • Cell Differentiation / drug effects
  • Cell Extracts / pharmacology*
  • Cell Movement / drug effects
  • Cell Proliferation / drug effects
  • Colony-Forming Units Assay
  • Culture Media / pharmacology*
  • Humans
  • Male
  • Mesenchymal Stem Cells / cytology
  • Mesenchymal Stem Cells / drug effects*
  • Platelet-Rich Plasma / chemistry*
  • Rats
  • Rats, Wistar


  • Cell Extracts
  • Culture Media