Directed Evolution: Bringing New Chemistry to Life

Angew Chem Int Ed Engl. 2018 Apr 9;57(16):4143-4148. doi: 10.1002/anie.201708408. Epub 2017 Nov 28.

Abstract

Tailor-made: Discussed herein is the ability to adapt biology's mechanisms for innovation and optimization to solving problems in chemistry and engineering. The evolution of nature's enzymes can lead to the discovery of new reactivity, transformations not known in biology, and reactivity inaccessible by small-molecule catalysts.

Keywords: biocatalysis; enzymes; heme proteins; protein engineering; synthetic methods.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Biocatalysis
  • Boranes / chemistry
  • Boranes / metabolism*
  • Cytochromes c / chemistry
  • Cytochromes c / metabolism*
  • Directed Molecular Evolution*
  • High-Throughput Screening Assays
  • Protein Engineering*
  • Rhodothermus / enzymology
  • Silanes / chemistry
  • Silanes / metabolism*

Substances

  • Boranes
  • Silanes
  • Cytochromes c