Molecular control of regulatory T cell development and function

Yohko Kitagawa; Shimon Sakaguchi

doi:10.1016/j.coi.2017.10.002

Molecular control of regulatory T cell development and function

Curr Opin Immunol. 2017 Dec:49:64-70. doi: 10.1016/j.coi.2017.10.002. Epub 2017 Oct 21.

Authors

Yohko Kitagawa¹, Shimon Sakaguchi²

Affiliations

¹ Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita 565-0871, Japan.
² Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita 565-0871, Japan. Electronic address: shimon@ifrec.osaka-u.ac.jp.

PMID: 29065384
DOI: 10.1016/j.coi.2017.10.002

Abstract

Treg cells expressing the transcription factor Foxp3 are essential for immunological tolerance and homeostasis. Recent genome-wide studies have revealed that Foxp3⁺ natural Treg cells possess a number of unique transcriptional and epigenetic features, which appear to be acquired along the course of Treg cell development and maintained throughout their lifespan. These studies also provide novel insights into how genomic variations contribute to genetic susceptibility to human autoimmune diseases by affecting Treg cell development and function.

Publication types

Review

MeSH terms

Animals
Autoimmune Diseases / genetics
Autoimmune Diseases / immunology*
Cell Differentiation*
Cell Self Renewal
Epigenesis, Genetic
Forkhead Transcription Factors / metabolism
Gene-Environment Interaction
Genetic Predisposition to Disease
Homeostasis
Humans
Immune Tolerance*
Lymphocyte Activation*
Polymorphism, Genetic
T-Lymphocytes, Regulatory / immunology*

Substances

FOXP3 protein, human
Forkhead Transcription Factors