Tubulin Post-Translational Modifications and Microtubule Dynamics

Int J Mol Sci. 2017 Oct 21;18(10):2207. doi: 10.3390/ijms18102207.


Microtubules are hollow tube-like polymeric structures composed of α,β-tubulin heterodimers. They play an important role in numerous cellular processes, including intracellular transport, cell motility and segregation of the chromosomes during cell division. Moreover, microtubule doublets or triplets form a scaffold of a cilium, centriole and basal body, respectively. To perform such diverse functions microtubules have to differ in their properties. Post-translational modifications are one of the factors that affect the properties of the tubulin polymer. Here we focus on the direct and indirect effects of post-translational modifications of tubulin on microtubule dynamics.

Keywords: acetylation; glutamylation; glycylation; methylation; microtubule dynamics; phosphorylation; polyamination; post-translational modifications.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Microtubules / metabolism*
  • Protein Processing, Post-Translational*
  • Tubulin / metabolism*


  • Tubulin