Roselle is cardioprotective in diet-induced obesity rat model with myocardial infarction

Life Sci. 2017 Dec 15;191:157-165. doi: 10.1016/j.lfs.2017.10.030. Epub 2017 Oct 21.

Abstract

Aims: Obesity increase the risks of hypertension and myocardial infarction (MI) mediated by oxidative stress. This study was undertaken to investigate the actions of roselle aqueous extract (R) on cardiotoxicity in obese (OB) rats and thereon OB rats subjected to MI.

Main methods: Male Sprague-Dawley rats were fed with either normal diet or high-fat diet for 8weeks. Firstly, OB rats were divided into (1) OB and (2) OB+R (100mg/kg, p.o, 28days). Then, OB rats were subjected to MI (ISO, 85mg/kg, s.c, 2days) and divided into three groups: (1) OB+MI, (2) OB+MI+R and (3) OB+MI+enalapril for another 4weeks.

Key findings: Roselle ameliorated OB and OB+MI's cardiac systolic dysfunction and reduced cardiac hypertrophy and fibrosis. The increased oxidative markers and decreased antioxidant enzymes in OB and OB+MI groups were all attenuated by roselle.

Significance: These observations indicate the protective effect of roselle on cardiac dysfunction in OB and OB+MI rats, which suggest its potential to be developed as a nutraceutical product for obese and obese patients with MI in the future.

Keywords: Cardiac function; Myocardial infarction; Obesity; Oxidative stress; Roselle.

MeSH terms

  • Animals
  • Anthocyanins / chemistry
  • Anthocyanins / isolation & purification
  • Anthocyanins / therapeutic use*
  • Antioxidants / therapeutic use*
  • Cardiotonic Agents / therapeutic use*
  • Diet, High-Fat / adverse effects
  • Heart / drug effects
  • Heart / physiopathology
  • Hibiscus* / chemistry
  • Male
  • Myocardial Infarction / complications*
  • Myocardial Infarction / drug therapy*
  • Myocardial Infarction / physiopathology
  • Obesity / complications*
  • Obesity / etiology
  • Oxidative Stress / drug effects
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / therapeutic use
  • Rats, Sprague-Dawley

Substances

  • Anthocyanins
  • Antioxidants
  • Cardiotonic Agents
  • Plant Extracts