Bone protective agents in children

Arch Dis Child. 2018 May;103(5):503-508. doi: 10.1136/archdischild-2016-311820. Epub 2017 Oct 24.

Abstract

Evaluation of bone health in childhood is important to identify children who have inadequate bone mineralisation and who may benefit from interventions to decrease their risk of osteoporosis and subsequent fracture. There are no bone protective agents that are licensed specifically for the prevention and treatment of osteoporosis in children. In this review, we discuss the mechanism of action and use of bisphosphonates and other new and established bone protective agents in children.

Keywords: bone disease; therapeutics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bone Density Conservation Agents / adverse effects
  • Bone Density Conservation Agents / therapeutic use*
  • Child
  • Diphosphonates / adverse effects
  • Diphosphonates / therapeutic use
  • Humans
  • Osteogenesis Imperfecta / drug therapy
  • Osteoporosis / etiology
  • Osteoporosis / prevention & control*
  • Osteoporotic Fractures / prevention & control

Substances

  • Bone Density Conservation Agents
  • Diphosphonates