ArachnoServer 3.0: an online resource for automated discovery, analysis and annotation of spider toxins

Bioinformatics. 2018 Mar 15;34(6):1074-1076. doi: 10.1093/bioinformatics/btx661.


Summary: ArachnoServer is a manually curated database that consolidates information on the sequence, structure, function and pharmacology of spider-venom toxins. Although spider venoms are complex chemical arsenals, the primary constituents are small disulfide-bridged peptides that target neuronal ion channels and receptors. Due to their high potency and selectivity, these peptides have been developed as pharmacological tools, bioinsecticides and drug leads. A new version of ArachnoServer (v3.0) has been developed that includes a bioinformatics pipeline for automated detection and analysis of peptide toxin transcripts in assembled venom-gland transcriptomes. ArachnoServer v3.0 was updated with the latest sequence, structure and functional data, the search-by-mass feature has been enhanced, and toxin cards provide additional information about each mature toxin.

Availability and implementation:


Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Automation, Laboratory
  • Disulfides / chemistry
  • Insect Proteins / chemistry
  • Peptides / chemistry
  • Spider Venoms / analysis
  • Spider Venoms / chemistry*


  • Disulfides
  • Insect Proteins
  • Peptides
  • Spider Venoms