Synthetic lipoprotein as nano-material vehicle in the targeted drug delivery

Drug Deliv. 2017 Dec;24(sup1):16-21. doi: 10.1080/10717544.2017.1384518.

Abstract

High-density lipoprotein (HDL) and low-density lipoprotein (LDL), as human endogenous lipoprotein particles, have low toxicity, high selectivity, and good safety. They can avoid the recognition and clearance of human reticuloendothelial system. These synthetic lipoproteins (sLPs) have been attracted extensive attention as the nanovectors for tumor-targeted drug and gene delivery. Herein, recent advances in the field of anticancer based on these two lipid proteins and recombinant lipoproteins (rLPs) as target delivery vectors were analyzed and discussed.

Keywords: High-density lipoprotein; low-density lipoprotein; nano-scaled vehicles; recombinant lipoprotein; targeted drug delivery.

Publication types

  • Review

MeSH terms

  • Animals
  • Drug Carriers / chemistry*
  • Drug Delivery Systems / methods
  • Excipients / chemistry
  • Humans
  • Lipoproteins / chemistry*
  • Lipoproteins, HDL / chemistry
  • Lipoproteins, LDL / chemistry
  • Nanoparticles / administration & dosage
  • Nanoparticles / chemistry*
  • Neoplasms / drug therapy

Substances

  • Drug Carriers
  • Excipients
  • Lipoproteins
  • Lipoproteins, HDL
  • Lipoproteins, LDL

Grants and funding

The Project Sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry. The work was also supported by Chongqing Key Research Project of Basic Science & Frontier Technology (No. cstc2017jcyjBX0012), Scientific and Technological Research Program of Chongqing Municipal Education Commission (Grant No. KJ1400523), Foundation Project of Chongqing Normal University (No. 14XYY020), Chongqing General Research Program of Basic Research and Frontier Technology (No. cstc2015jcyjA10054), Chongqing Normal University Postgraduate's Research and Innovation Project (No. YKC17004), Open Foundation Project of Engineering Research Center for Bioactive Substances (No. AS201614), Chongqing University Students' Training Project of Innovation & Undertaking (No. 201610637076), and Chongqing Research Program of Basic Research and Frontier Technology PR China.