Brain penetration of orally administered sodium pyroglutamate

J Pharm Pharmacol. 1988 Aug;40(8):584-5. doi: 10.1111/j.2042-7158.1988.tb05311.x.

Abstract

The absorption and brain penetration of [3H]pyroglutamate was determined after oral administration to rats. Gas-liquid chromatography of the methylated derivatives followed by mass fragmentometry was used to analyse the plasma and brain levels of pyroglutamate. [3H]Pyroglutamate was separated from other labelled compounds by thin layer chromatography. The administration of 500 mg kg-1 [3H]pyroglutamate resulted in a 30-fold increase in plasma levels and a doubling in the brain levels. Over 60% of the cerebral radioactivity was present as [3H]pyroglutamate demonstrating that pyroglutamate is not only well absorbed but also penetrates in significant amounts into the brain.

MeSH terms

  • Animals
  • Brain / metabolism*
  • Chromatography, Thin Layer
  • Gas Chromatography-Mass Spectrometry
  • Male
  • Pyrrolidinones / pharmacokinetics*
  • Pyrrolidonecarboxylic Acid / blood
  • Pyrrolidonecarboxylic Acid / pharmacokinetics*
  • Rats
  • Rats, Inbred Strains

Substances

  • Pyrrolidinones
  • Pyrrolidonecarboxylic Acid